Negative memory storage affects depression symptomsAugust 13, 2019 - 16:19 AMT PanARMENIAN.Net - Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to research in mice published in JNeurosci. Inhibiting these manifestations could be a future treatment route, Medical Xpress says. Groups of neurons that are activated after an experience are thought to be the physical representation of memory. These so-called engrams in the hippocampus could be involved in depression, which is characterized by impaired recall of positive memories and increased recall of negative memories. In a mouse model of depression, Tak Pan Wong and colleagues at Douglas Hospital Research Centre tagged the engrams that formed after mice experienced social stress and examined their social avoidance behavior. Even though all mice experienced the same stressor, only some displayed depression behaviors, indicating a predisposition to developing depression. The depression-prone mice displayed higher concentrations of engram cells compared to the less susceptible mice, and the density of the cells correlated with the level of social avoidance behavior. Activating the engram cells increased social avoidance behavior while suppressing the cells decreased it, suggesting a role in the cognitive symptoms of depression. Top stories Authorities said a total of 192 Azerbaijani troops were killed and 511 were wounded during Azerbaijan’s offensive. In 2023, the Azerbaijani government will increase the country’s defense budget by more than 1.1 billion manats ($650 million). The bill, published on Monday, is designed to "eliminate the shortcomings of an unreasonably broad interpretation of the key concept of "compatriot". The earthquake caused a temporary blackout, damaged many buildings and closed a number of rural roads. Partner news | Czech-Armenian military cooperation discussed in Yerevan A delegation led by the Director General for the Industrial Cooperation Division of the Ministry of Defence of the Czech Republic visited Armenia. U.S. welcomes efforts to define Armenia-Azerbaijan border The United States welcomes efforts to define the border between Armenia and Azerbaijan, says Vedant Patel. Biden honors resilience of Armenian people on April 24 U.S. President Joe Biden has issued a statement on the 109th anniversary of the Armenian Genocide. Ex-Karabakh leader moved to solitary confinement cell in Baku, his son says David Vardanyan is the son of former Karabakh leader Ruben Vardanyan who who is currently imprisoned in Azerbaijan. |