Iran's Supreme Leader has warned against undermining negotiators engaged in talks with the West over its nuclear programme, according to The Associated Press.

Ayatollah Ali Khamenei has come out in support of President Hassan Rouhani's policy of outreach to the West. His remarks come ahead of a new round of talks scheduled for Thursday, November 7 in Geneva.

Diplomats "are on a difficult mission and nobody should weaken those who are on assignment," Khamenei is quoted as saying.

"Nobody should consider our negotiators as compromise-seekers," he added.

Iranian officials maintain that the country will not concede what it considers to be its fundamental right to nuclear activity, and that the United States remains its enemy.

"From one hand, the Americans smile and show interest in talks but on the other hand they immediately say all options are on the table," Khamenei was quoted as saying by state TV.