The World Health Organization (WHO) calls depression one of the most serious mental disorders, and researchers around the world are trying to improve treatment of the disease.

Now in the largest meta-analysis ever carried out, researchers from iPSYCH have shown that medicine which inhibits inflammation such as arthritis medicine can also be effective in the treatment of people suffering from depression, Medical Xpress reports.

"Our study shows that a combination of anti-inflammatory medicine, which is what arthritis medicine is, and antidepressants can have an additional beneficial effect on patients with a depression. The effect was also present when anti-inflammatory medicine was compared with a placebo in patients with a physical disease and depressive symptoms," explains one of researchers behind the study, Ph.D. student and medical doctor Ole Köhler-Forsberg from Aarhus University and Aarhus University Hospital, Psychiatry.

Six different medications showed an effect on depression

The analysis is based on 36 international studies with a total of 9,422 patients who either suffered from depression or had depressive symptoms. The results have been published in Acta Psychiatrica Scandinavica.

In addition to looking into arthritis medicine, the researchers also examined the effect of other forms of medication which have an anti-inflammatory effect, including glucocorticoids and the antibiotic minocycline, adrenocortical hormone and the statins that are used in the treatment of high cholesterol levels. All of them showed antidepressant effects.

"This definitely bolsters our chances of being able to provide personalised treatment for individual patients in the longer term. Of course we always have to weigh the effects against the potential side-effects of the anti-inflammatory drugs. We still need to clarify which patients will benefit from the medicine and the size of the doses they will require. The findings are interesting, but patients should consult their doctor before initiating additional treatment," says Ole Köhler-Forsberg.

He emphasises that the biggest challenge with depression is that we still do not know what triggers the disease in a particular individual.

"Some studies suggest that the choice of antidepressant can be decided by a blood sample that measures whether there is an inflammatory condition in the body. Other studies show that the same blood sample can be used as a guideline for whether a depressive patient can be treated with anti-inflammatory medicine that has a better effect when there is inflammation present at the same time as the depression. However, we need to verify these findings and examine which patients can benefit from this before it can be implemented in everyday clinical practice," Ole Köhler-Forsberg says.